The Bruins lost the first two games of the series in very close contests, 1–0, on a goal with less than 19 seconds left in regulation, and then 3–2 in overtime. Game 3 did not start well for the Bruins either, as they lost Nathan Horton to injury at the 5:07 mark of the first period following a late hit by Canucks defenseman Aaron Rome that left Horton prone on the ice for nearly 10 minutes. Despite losing Horton to a devastating hit, the Bruins defeated the Canucks, with 4 goals in each of the second and third periods, twice scoring short-handed goals, and going on to win, 8–1. It was the highest score by one team, and largest winning margin, in a Finals game since 1996. Game 4 saw the Bruins defeating the Canucks in a 4–0 shutout.

The home team continued to be the winner, with Game 5 in Vancouver going to the Canucks in a 1–0 shutout, then Game 6 going to the Bruins, who staved off elimination with a 5–2 defeat of the Canucks. The Bruins set a new record for the quickest four goals ever in a playoff series game, scoring in only 4:14 of game time in the first period of Game 6. Game 7, which was played in Vancouver on June 15, was the first time the Bruins have ever played in Game 7 of the Stanley Cup Finals. The Bruins shut out Vancouver 4–0, winning the sixth Stanley Cup in franchise history and breaking a 39-year Cup drought. The 2010-11 Bruins were the first team in NHL history to win a Game 7 three times in the same playoff run.